Human Granulocyte Colony - Stimulating Factor Specifically Binds to Murine Myeloblastic NFS - 60
نویسندگان
چکیده
The specific binding of human granulocyte colony-stimulating factor (G-CSF) to its receptors on NFS-60 cells acts as a primer for cellular proliferation. There are approximately 400 binding sites per cell. with a binding constant of about 1 00 pmol/ 1. Before the proliferative response, the affinity constant of the membrane particulate fraction to labeled guanosine triphosphate-gamma-S ( ‘S-GTPyS) and the intracellular cyclic adenylate monophosphate (cAMP) level increased in the presence of G-CSF to about 2.5-fold
منابع مشابه
Human granulocyte colony-stimulating factor specifically binds to murine myeloblastic NFS-60 cells and activates their guanosine triphosphate binding proteins/adenylate cyclase system.
The specific binding of human granulocyte colony-stimulating factor (G-CSF) to its receptors on NFS-60 cells acts as a primer for cellular proliferation. There are approximately 400 binding sites per cell, with a binding constant of about 100 pmol/L. Before the proliferative response, the affinity constant of the membrane particulate fraction to 35S-labeled guanosine triphosphate-gamma-S (35S-G...
متن کاملHuman Granulocyte Colony - Stimulating Factor Specifically Binds to Murine
The specific binding of human granulocyte colony-stimulating factor (G-CSF) to its receptors on NFS-60 cells acts as a primer for cellular proliferation. There are approximately 400 binding sites per cell. with a binding constant of about 1 00 pmol/ 1. Before the proliferative response, the affinity constant of the membrane particulate fraction to labeled guanosine triphosphate-gamma-S ( ‘S-GTP...
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